Yosemite | Mal & Jay

View More: https://andreadavidoc.pass.us/malloryandjay
Wow, wow.

All I can say to start off is how completely blown away I am by the couples I meet. It’s pretty intimidating when you realize how much trust people put in you when they ask you to document a very special part of their life. Mallory & Jordan were just #ANOTHERONE …
sorry, I had to heh heh. I had met Jay at his sister’s wedding almost a year and a half ago, and it was really crazy to realize that he was Mallory’s fiancé when she reached out to me to take their engagement photos.

Firstly, he proposed in Aspen, Colorado. Paradise for the snowboarding duo. Keeping up with the winter theme, they wanted to do their photos in the snow. At first, we planned for Big Bear. NOPE. After talking to my friend Djae, I had the crazy idea to text Mallory and see if they were game to going all the way to Yosemite and once they said yes in a matter of days, I knew this couple was too down. TOO DOWN.

Aside from having the snow, the falls, the mountains and everything in-between, what made this day super memorable for me was hearing their story when we went to dinner. They were so incredibly open and honest with me that at times, I seriously was trying to stop myself from tearing up. Okay, I for sure teared up, but I was willing myself from letting that tear roll down my face. HAHA.

Mal and Jay are long-time lovers. Ever since high school actually. But to be frank, they had time apart. It wasn’t necessarily a bad end, but with starting college, moving, the questioning of identities, and the ever-lasting struggle of being content with your own individuality, they went their separate ways. It was pretty darn separate. They said that they didn’t speak for about two years. During this time, Mal moved up north to play college soccer and Jay was getting ready to go to the navy.

One fateful day, an uber driver dropped off Jay at a sidewalk in LA for a wedding showcase event. He was accompanying his sister and that driver dropped him right in front of where a certain someone was working the event. That someone was Mal. She’s also a boss in the wedding industry and plans weddings. They made eye-contact, but none of it was verbal and long-story short, that spiraled a huge tornado of emotions, leading them to meet up soon after to talk.

They talked about their time apart. Thinking it would be a tense conversation, they instead talked comfortably about how they’ve grown, how they’ve learned to be independent, how God has shaped their lives. How although they tried to forget their lives with each other, filling that human void with something that wasn’t Jay or something that wasn’t Mal just didn’t work. Can you imagine? You haven’t seen someone whom you loved in two years and seeing them for the first time, you think they’d be a stranger, but it feels familiar and warm.

Weeks pass by and Jay goes to the navy. He says that he expected to feel alone, but little did he know he would meet God-given brothers that were there, side-by-side through the pushups and the fatigue and the strenuous training until now, still side-by-side during his newly engaged season. They kept in contact though. Mal didn’t want to be attached to him while he was away, but basically, she picked him up from the airport, and he told her he didn’t want to be without her. They were back together ever since, this time better than ever. They needed to be apart to be better for each other and better for themselves.

A couple years later, we have a snowboarding trip in Aspen, a promise, a ring, and now we’re here. Something supernatural happened that day in LA. Out of all the places that uber driver could have dropped Jay off, it was face-to-face with his future bride that he always had a his heart set on.

Either I’m just super sensitive or my couples take pleasure in making me cry, but when I was eating dinner with Mallory and Jordan, I knew that’s where I was supposed to be and that everything leading up to this dinner just happened for a reason. I loved how their photos came out, sure, very important, but it was an insane moment for other reasons. I left feeling inspired, hopeful, and strong, especially in a time where I wouldn’t necessarily use those three words to describe myself. I’m not very good at receiving affirmations, I’ve said this a lot in the past couple weeks and it’s become a bit of an inside joke. I get super awkward and in an effort to not seem overly-humble, I tense up a bit. Not sure why, maybe the bio major stress pushed me off an incredibly high horse. However, on this night, my friends who were in Yosemite had left before the shoot and I was alone for the night and the rest of the Norcal journey. Mallory and Jay drove a separate car on the way out of the park in the dark; a one and a half hour drive that’s not fun. By this time, it would be my third time driving this road out of the park. Later they told me they in the car, they said I was a “tough chick.” Maybe it was for driving a long windy-road alone in the dark, but I had the inclination they were suggesting something a bit more. I’d like to think I’m a tough chick, but sometimes it’s hard to feel so tough when you are sometimes so blue and overwhelmed. Although a short remark, it definitely resonated with me in the days to come. It helped remind me that I am strong, in times when I want to be strong for others yet forget about myself and the joy that I experience when I’m doing what God drives me to do.

All-in-all, I’m eternally thankful for these two. For their example, their charisma, the laughs we had, and their friendship. I’m also thankful that they trusted me to meet in a forest six-hours away with no service at a location we pinned the night before in a thirty-minute time frame where I had to give them the make and model of my car in order to identify me in such a vast space. I’m also taking this moment to thank all the other friends I’ve made before them who lift me up. You guys have given me a great track record. No client horror stories yet. Knocking on wood.

Here’s a taste of their photos. Who’s going to be next. I got a National Park Pass now guys…let’s go.

ALSO, GIF.

vivagarcia
View More: https://andreadavidoc.pass.us/malloryandjay
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Что эффективнее, софосбувир и даклатасвир или софосбувир и велпатасвир?
Ученые из департамента по делам ветеранов, Службы здравоохранения населения, Системы здравоохранения Пало-Альто, Калифорния, США, решили все таки выяснить, что же эффективнее для лечения 2 и 3 генотипа вируса гепатита С софосбувир и даклатасвир или софосбувир и велпатасвир?

Цель

Понимание реальной эффективности схем пероральной терапии гепатита С (HCV) позволяет принимать решения о лечении. Мы оценили эффективность даклатасвира + софосбувира ± рибавирина (DCV + SOF ± RBV) и велпатасвира / софосбувира (VEL / SOF) ± RBV у пациентов с генотипом 2 и генотипом 3 инфекции, получавших лечение в обычной практике.
Cравнивали частоту Устойчивых Вирусологических Ответов (далее по тексту УВО) Этот обсервационный анализ был проведен в когорте пациентов с намерением лечить гепатит С генота 2 и генотипа 3. Анализ устойчивого вирусологического ответа (УВО) был получен у 5400 пациентов, начавших лечение DCV + SOF ± RBV или VEL / SOF ± RBV, что действительно может говорить, об серьезности доказательной базы.

Результаты

Для генотипа 2 показатели УВО не различались между DCV + SOF (94,5%) и VEL / SOF (94,4%) или между DCV + SOF + RBV (88,1%) и VEL / SOF + RBV (89,5%). Для генотипа 3 показатели SVR не различались между DCV + SOF (90,8%) и VEL / SOF (92,0%) или между DCV + SOF + RBV (88,1%) и VEL / SOF + RBV (86,4%). В многомерных моделях пациентов с генотипом 2 и 3, режим лечения не был значимым предиктором шансов УВО. Для генотипа 3 значимыми предикторами снижения шансов УВО были предшествующий опыт лечения ВГС (отношение шансов 0,51, 95% CI 0,36–0,72; p 3,25 (OR 0,60; 95% CI 0,43 –0,84; р ?= 0,002) и декомпенсированный цирроз печени (ОШ 0,68; 95% ДИ 0,47–0,98; р?= 0,04). Для пациентов с генотипом 2 и 3, получавших VEL / SOF ± RBV, 89% и 85% получали 12-недельное лечение соответственно. Для DCV + SOF ± RBV 56% и 20% пациентов с генотипом 2 HCV получали 12-недельное и 24-недельное лечение соответственно; в то время как 53% и 23% пациентов с генотипом 3 ВГС получали 12 недель и 24 недели, а большинство пациентов получали 24 недели.

Выводы

У пациентов, инфицированных генотипом 2 и 3 ВГС, DCV + SOF ± RBV и VEL / SOF ± RBV вызывали одинаковую частоту УВО в каждом генотипе, и режим не оказывал значительного влияния на шансы УВО. Для пациентов с генотипом 3 предшествующий опыт лечения и прогрессирующее заболевание печени были значимыми предикторами снижения шансов УВО независимо от режима.

Резюме

В клинической практике показатели излечения для генотипа 2 вируса гепатита С (ВГС) составляли 94%, а показатели излечения для генотипа 3 ВГС – 90%. Вероятность достижения излечения была одинаково независимой от того, получал ли человек даклатасвир плюс софосбувир или велпатасвир / софосбувир. Рибавирин не влиял на показатели излечения. Вероятность излечения была самой низкой у людей, которые получали терапию от ВГС в прошлом.

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Carbon capture and storage involves the separation of carbon dioxide from other gases, after which it’s pumped underground for storage. It’s likely to be needed to reach our climate goals without simply shutting down many existing fossil fuel plants, and it will be essential if we overshoot our emissions goals by mid-century. But it also adds significant costs to building and operating fossil fuel plants, which explains why the process has never gotten past the point of sporadic demonstration projects.

An alternative to storage involves turning the carbon that’s captured into a useful product—something the XPrize has made one of its challenges. Doing so requires two things: overcoming the chemical stability of CO2 and making a product that sells at a profit. We recently stumbled across a bit of creative chemistry that turns carbon dioxide from the air into a product that should be profitable: high-quality carbon nanotubes.
Something in the air
Our current methods for making carbon nanotubes typically rely on hydrocarbons. The chemistry of this source helps drive the tube-forming reactions, since it can be energetically favorable to remove the hydrogens from these molecules. Unfortunately, this doesn’t get rid of CO2, and it’s only good for emissions in the sense that some of the carbon ends up in nanotubes instead of the air.

But the new paper relies on some dramatically different chemistry to supply the carbon. It uses an electrochemical process to deposit carbon at one electrode and liberate oxygen at a second. And it relies on a molten salt that decomposes during the process and regenerates itself by sucking CO2 out of the air.

The salt in question is lithium carbonate, or Li2CO3, which is molten at a reaction temperature of 723°C. Decomposition produces dilithium oxide (Li2O, but not as dilithium crystals), and liberates both carbon and oxygen. The oxygen gets released in molecular form (O2) at the anode thanks to an aluminum oxide catalyst. And the carbon gets deposited on an iron catalyst on the cathode—under these conditions, it forms carbon nanotubes. The Li2O, meanwhile, reacts with carbon dioxide in the air and re-forms the lithium carbonate salt.

The research largely focused on controlling the growth of the nanotubes. All nanotubes are variations on a theme, with a hexagonal mesh of carbon atoms rolled into a cylinder. But the spacing between atoms allows nanotubes with different diameters. It’s also possible to have a series of concentric tubes, with each wrapped around a smaller one—these are called “multiwalled.” Smaller diameters and single-walled tubes are generally worth more, so the researchers focused on adopting the molten salt synthesis to produce the most valuable nanotubes.

Not in control
The gist of the research is that it’s a challenge. Although the iron-based catalyst was initially layered evenly on top of the cathode, the high temperatures allowed it to move around. As a result, it formed little bubbles on the surface of the electrode, with the size of the bubbles being dependent upon the thickness of the layer that formed them. The size of those bubbles, in turn, helped determine the size of the nanotubes that formed on them. So, the best way to get a small-diameter nanotube is to use a very thin layer of catalyst to start with.

The problem was that this relationship didn’t hold for long. If the reaction was stopped quickly—after three minutes—more of the nanotubes were narrow in diameter. But if the reaction was continued for a half-hour, the diameters gradually crept up. An examination of the electrode showed that, over time, diffusion of the catalyst drew it into larger and larger bubbles, and the diameter of the nanotubes grew accordingly. So, there’s still some work to do with structuring the catalyst.

(catalog printing printing in China).

But the authors did some calculations that suggest doing so could be worth the effort. If you figure out the cost of the electricity needed to heat the salt up and drive the reactions, it costs half of what you can sell the nanotubes for.

That’s not to suggest that this means we’ve figured out how to sequester carbon. The market for nanotubes is pretty small, so even making all of our carbon nanotubes this way wouldn’t put a dent in our massive emissions. But it’s a nice demonstration that some interesting things are possible when we step beyond the typical chemistry, and it hints that it might be possible to do similar things on much larger scales.

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